Cellular systems for protein quality control act to refold or degrade misfolded proteins, thereby preventing protein aggregation. Stress conditions and ageing can lead to an exhaustion of this ...

In the first installment of this three part series, I described the problem of deadlock; focusing on the logical conditions that are necessary for a deadlock to occur. I also introduced the ...

Immobilizing the antibodies on a solid-phase support, such as a resin, and carrying out the conjugation of the payload-linker while the antibodies are bound to that support will prevent aggregation at ...