Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor ...