Regulators, developers, and testing laboratories are exploring in silico models, transporter assays, and other options to better predict drug combination outcomes In the future, many drug–drug ...

Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC). This is an ASCO ...

The most common manifestation of pharmacokinetic interactions with warfarin involves the inhibition or induction of its metabolism. Attention should be paid to the relative importance of the warfarin ...

Brain cytochrome P450 (CYP) enzymes represent a specialised set of metabolic proteins that, while less abundant than their hepatic counterparts, play an increasingly acknowledged role in the local ...

A team of mathematicians and pharmaceutical scientists collaborated to identify the major cause of the low accuracy of the equation in the FDA guidance used to predict drug-drug interaction through an ...

Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

† The combination of variants were unusual and an allele designation was not available at analysis. ‡ Percentage for duplications based on number of patients and not number of alleles. Duplications ...

Iam not an expert in managed care.Instead, I have spent a considerableamount of time trying to understanddrug—drug interactions (DDIs) in terms ofthe mechanisms underlying such interactions,the way ...

Pathology Data in the Central Databases of Multicenter Randomized Trials Need to Be Based on Pathology Reports and Controlled by Trained Quality Managers PURPOSE: This review of drug interactions in ...

The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified in ...