Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that cannot be cured and that has substantial personal, social, and economic costs. The long-term prognosis is poor: ...

Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...

The study identified 32 differentially expressed proteins in IPF, highlighting cytokine dysregulation as a key molecular feature of the disease. Five hub proteins—FGF2, HGF, HBEGF, ERBB3, and ...

Alveolar fibroblasts play a key role in regulation of lung inflammation. Pseudomonas aeruginosa (PAO) is one of the most ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Bacteria in the human gut can directly deliver proteins into human cells, actively shaping immune responses. A consortium led ...

Cytokines are secreted proteins critical for immune regulation, cell signaling, and tissue homeostasis. These cells are increasingly recognized as key tools in biomedical research, particularly in ...

A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...

Cancer patients often lose excessive amounts of weight. This affects up to 80% of patients and is mainly due to a decrease in muscle mass and fatty tissue. This cancer-induced cachexia (CIC) is ...