Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Particle therapy, including proton and carbon ion radiotherapy, represents a major advancement in cancer treatment due to its ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...