Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

An artist’s depiction of an artificially evolved enzyme breaking a silicon-carbon bond. [Caltech/Dow] For the first time, scientists have engineered an enzyme that can break the stubborn man-made ...

Stereoview of mutation loci in mPlum based on the crystal structure of DsRed. Red: the RFP chromophore; yellow: emission shift mutations; gray: neutral mutations. A team of researchers at the ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Barcoding technologies that take advantage of the high information content that can be encoded in oligonucleotide sequences have enabled a wide array of applications in biotechnology, particularly ...