Cytoplasmic dynein is a vital microtubule-based motor protein that drives retrograde intracellular transport, supporting essential cellular functions ranging from organelle positioning to cell ...

LA JOLLA, CA - Feb. 9, 2018 - On the cellular highway, motor proteins called dyneins rule the road. Dyneins "walk" along structures called microtubules to deliver cellular cargo, such as signaling ...

Understanding this motion may help to tackle health problems that affect cilia, which range from fertility issues to lung disease and COVID-19. Using cryo-electron tomography, researchers have ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 8 (Feb. 24, 2009), pp. 2647-2652 (6 pages) Translocation from the cytoplasm to the nucleus is required ...

Microtubule motor proteins can be either plus end motors or minus end motors depending on the direction of movement. Mitosis requires the trafficking of proteins along microtubules to produce two ...

A mechanism of dynein-powered metastatic locomotion has been identified using soft tissue models, revealing a new clinical target for breast cancer treatment. New research led by Penn State (PA, USA) ...