It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed ...

A comprehensive analysis has identified novel enhancers associated with neuronal development and disease. An international collaboration of researchers led by Masahito Yoshihara at Chiba University ...

Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to guide healthy development, growth, and maintenance of our body systems over ...

Tsukuba, Japan - Genes encode proteins and proteins dictate cell function. Therefore, the thousands of genes expressed in a cell determine what that cell can do. Among the multiple elements that are ...

The renin-angiotensin system plays an essential role in blood pressure homeostasis. To address the molecular mechanisms controlling hypertension-responsive mouse renin (mRen) gene regulation, ...