Targeted Oncology

IGF-1 and GLP-1 Shape Liposarcoma Development, Presenting Potential Targets

Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...
Medscape

Targeting Cancer Cells -- More Pathways, More Inhibitors, More Trials

The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
Targeted Oncology

Erica Pimenta, MD, PhD

Erica Pimenta, MD, PhD, is an instructor at Harvard Medical School and physician-scientist at Dana-Farber Cancer Institute Erica Pimenta, MD, PhD, discussed the goals and key findings from her and her ...
Kaleido Scope

In Type 1 diabetes, verapamil prevents decline of IGF-1 and promotes beta-cell IGF-1 signaling

Now UAB researchers, led by Guanlan Xu, Ph.D., and Shalev drilled down further into the mechanism underlying verapamil’s beneficial effect. In a paper published in Diabetes, they show that, in Type 1 ...
The American Journal of Managed Care

Plasma IGF-1 Could Be Important Parkinson Disease Biomarker

Levels of the hormone increase with disease severity, a new study has found. Plasma levels of insulin-like growth factor 1 (IGF-1) could give clinicians a better understanding of whether a patient ...