The first systematic whole genome sequencing study of how chemotherapy damages healthy tissues has shown that many, but not all, of these agents cause mutations and premature aging of normal blood ...

Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small ...

KRAS mutated endothelium promotes the occurrence and development of AVMs through a variety of ways, including promoting EndMT, angiogenesis, VEGF signaling pathway and pericyte loss. KRAS mutation in ...

What if doctors could look at a person’s DNA and not only spot a harmful mutation, but also predict the kind of disease it may cause—before symptoms fully appear? Scientists at the Icahn School of ...