Swedish Orphan Biovitrum AB: Sobi to advance Gamifant (emapalumab) in interferon-gamma-driven sepsis (IDS) based on EMBRACE topline data

Sobi (STO: SOBI) today announced that topline results from the Phase 2a EMBRACE study evaluating Gamifant (emapalumab) for interferon-gamma (IFN?)-driven ...
News Medical

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain. The resulting ...
Science Daily

The interferon gamma receptor pathway is necessary for CAR T-cell mediated killing in solid tumors

Researchers have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy. Researchers at ...
ascopubs.org

The prognostic impact of transforming growth factor beta 2 (TGFB2) mRNA levels, in conjunction with interferon-gamma receptor activation of interferon regulatory factor 5 (IRF5 ...

Novel TROP2-targeted CAR T cells with high specificity and sustained efficacy for solid tumors in animal models. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...
Medscape

Validated Assay Can Test for Interferon Activity in Pediatric Inflammatory Diseases Using Biomarkers

CHICAGO — The use of a clinically validated flow cytometry test can assess type 1 and type 2 interferon activity in children with various pediatric inflammatory diseases to evaluate and monitor their ...