Although epistasis is an important phenomenon in the genetics and evolution of complex traits, epistatic effects are hard to estimate. The main problem is due to the overparameterized epistatic ...
Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 30, No. 2 (1981), pp. 116-124 (9 pages) This paper develops a maximum likelihood method for estimating a piecewise ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 19 (May 10, 2011), pp. 7860-7865 (6 pages) The substitution rate in a gene can provide valuable ...
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