The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

Having considered localization of respiratory functions in mitochondria and in prokaryotic cells, it's time to return to the ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists have investigated a multi-enzyme complex that plays an essential role in metabolism ...

Pyruvate formate-lyase (PFL) from Escherichia coli uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine residues (Cys 418, Cys 419). We ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...

Researchers at Duke University Medical Center and Wake Forest University School of Medicine have identified ALDH4A1, a mitochondrial proline-metabolizing enzyme, as a third structural component of the ...

Specific activities of β-oxidation and tricarboxylic acid cycle enzymes, and enzymes related to glycolysis and glycogenesis, were determined in parasitic females of Strongyloides ratti, the ...

Biology is full of molecular machines, such as motor proteins and ATP synthase, that operate self-sufficiently through cycles of oxidation and reduction. A team of human chemists at the University of ...

KANSAS CITY, MO -- Researchers in the Workman Lab at the Stowers Institute for Medical Research have identified a link between cellular metabolism and gene expression, one with potentially ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...