At fertilization, the animal genome is inactive, and the earliest stages of development are driven by pre-existing proteins and RNA transcripts that have been stored in the egg. As the fertilized egg ...
Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...
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