ANDOVER, Mass.--(BUSINESS WIRE)--DeuteRx, LLC, is a research and development-focused biotechnology company dedicated to improving racemic small molecule marketed drugs and drug candidates intended for ...

Making carbon–carbon bonds is hard. Linking racemic mixtures of two alkyls while simultaneously controlling the stereochemistry of both ends of the product is nigh on impossible. Now Gregory Fu, ...

THE separation of racemic mixtures of optical isomers is still limited, with rare exceptions, to the methods of Pasteur. For this reason the resolution of substances which seem identical in the ...

From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

When chemists need to separate one chiral molecule from a mixture of enantiomers—for instance, when synthesizing potential drug molecules—they often turn to high-performance liquid chromatography ...

Gel permeation chromatography was performed on a liquid chromatography system (JASCO Co., Hachioji, Japan) that was composed of a PU-2089 HPLC pump and an 860-CO column oven (operated at 35 °C) and ...

A quote from Rudolph Buchheim, an experimental pharmacologist who lived from 1820 to 1879, summarizes the nature and importance of studies in drug metabolism, including the pharmacokinetics and ...

As a general rule, disclosure of a drug material comprised of a mixture of components, without more, does not render obvious a specific component of that mixture. See, e.g., In re May, 574 F.2d 1082, ...

Enantiomers are two molecules with the same chemical composition, mirror images of each other, which do not overlap. Produced in equal quantities during a chemical reaction, they may exhibit opposite ...