Multiple studies have shown STAT3 to be a tumor microenvironment modulator and a cancer driver, making it one of the most alluring targets in oncology and immune-oncology. The production of STAT3 ...
Significance of MYC rearrangement and chemotherapy type on survival outcomes of patients with central nervous system lymphoma.
Pooled patients treated with TTI-101 demonstrated a 9.4% decrease from baseline in fibrosis score at week 12, compared to a 2.4% decrease for the ...
Figure 1: (A) Canonical STAT3 activation pathway. (B) WP1066 and TTI-101, examples of small molecule STAT3 inhibitors that are cell penetrant. Pediatric H3K27M-mutant diffuse midline gliomas (DMGs), ...
Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
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