With the rise of multidrug resistance, Pseudomonas aeruginosa infections require alternative therapeutics. The injectisome (iT3SS) and flagellar (fT3SS) type III secretion systems are 2 virulence ...
With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...
Type 3 secretion systems (T3SSs) are used by several pathogenic bacterial species to deliver effector proteins, responsible for the effects of infection, into the target host cells. An MGH research ...
Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...
The gut–islets axis connects nutrient sensing in the intestine with insulin secretion from the pancreas and plays an essential role in glucose regulation. GLP-1 released by intestinal L cells can ...
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