Understanding how immune cells coordinate within the tumor microenvironment is essential for developing effective cancer immunotherapies. While CD8⁺ cytotoxic T cells are central to anti-tumor ...
Herpesviruses use elaborate strategies to establish themselves in their host including evading, destroying or redirecting immune cells. In June 15 Journal of Clinical Investigation, Coscoy and Ganem ...
EVOLVE Platform Integrates Differentiated T Cell Costimulation Approach with Unique Insights into Solid Tumor Features to Optimize Discovery and Clinical Development of Differentiated Precision ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 18 (May 3, 2022), pp. 1-12 (12 pages) B and T lymphocytes of the adaptive immune system undergo ...
Adding CD28 costimulation to cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cells targeting CD70+ cancers significantly enhanced antitumor efficacy and long-term cytotoxicity ...
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