Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific targets ...

Balanced reciprocal translocations associated with genetic disorders have facilitated the identification of a variety of genes for early-onset monogenic disorders, but only rarely the genes associated ...

A recent review shows the role of chromosomal translocations in causing a range of cancers. Emerging, personalized therapies target these translocations. A broken chromosome is like an unmoored ...