Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, race in eGFR equations is a ...

Chemists discovered how the epidermal growth factor receptor changes its shape when it binds to its target, and how those changes trigger cells to grow and proliferate. Receptors found on cell ...

In a recent study published in the journal Nature Biotechnology, researchers in Switzerland used base and prime editing to create and analyze a wide array of variants of the epithelial growth factor ...

The activity of the epidermal-growth-factor receptor is highly regulated during Drosophila development. Two negative-feedback loops involving the proteins Kekkon1 and Sprouty have been found to act by ...

Renin–angiotensin system (RAS) inhibitors — including angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) — slow the progression of mild or moderate chronic kidney ...

Epidermal growth factor receptor (EGFR) is a protein on the surface of your cells that helps them grow. When the gene that codes for EGFR has a mutation, it affects the way this protein works, causing ...

HER2 overexpression in gastric cancer ranges from 9% to 23% and is more frequent in the intestinal subtype; its prognostic value remains unclear, but HER2 should be tested in all patients with ...

EGFR-positive lung cancer is a type of non-small cell lung cancer (NSCLC). It can cause symptoms such as breathing problems and hoarseness. Therapy that targets the mutation, such as EGFR inhibitors, ...

The estimated glomerular filtration rate (eGFR) is a blood test to assess kidney function. The formula for calculating eGFR takes the patient’s body size, age, and sex into account to predict how well ...

CAMBRIDGE, MA – Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment. MIT chemists have now discovered how one of these ...