CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence …

Nov 13, 2025 · CTCF (CCCTC-Binding Factor) is a Protein Coding gene. Diseases associated with CTCF include Intellectual Developmental Disorder, Autosomal Dominant 21 and Ctcf-Related …

CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific …

CTCF is defined as a ubiquitously expressed zinc finger DNA-binding protein that functions as a transcription factor and insulator, regulating gene expression by blocking enhancer-promoter …

Dec 16, 2022 · CTCF (CCCTC-binding factor) is an 11-zinc-finger DNA binding protein which regulates much of the eukaryotic genome’s 3D structure and function. The diversity of CTCF binding motifs …

CTCF uses various combinations of its 11 zinc fingers to recognize a variety of unrelated DNA sequences. Once bound to DNA, CTCF can function as a transcriptional insulator, repressor, or …

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation.

Jul 14, 2025 · CCCTC-binding factor (CTCF) is a highly conserved and multifunctional DNA-binding protein that plays a central role in the organization of the three-dimensional (3D) structure of the …

May 10, 2023 · CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind …

Feb 28, 2025 · CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not …