Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and …

Properdin, the widely known positive regulator of the alternative pathway (AP), has undergone significant investigation over the last decade to define its function in inflammation and disease, …

Definition 44, 45 Properdin (CFP) is the only gene of the complement system that is located on the X chromosome, expressed by monocytes and T cells. It is one of the more common …

Jan 12, 2023 · Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers...

Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative pathway activity. Properdin is produced by many …

Citation: 'properdin' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. …

Sep 4, 2019 · Here, we report crystal structures of monomerized properdin, which was produced by co-expression of separate N- and C-terminal constructs that yielded monomer-sized …

Properdin is a protein that plays a crucial role in the activation of the alternative complement pathway, a key component of the innate immune system's chemical defenses against pathogens.

The properdin gene is located on the X chromosome and deficiency leads to impaired alternative pathway function, leaving patients highly susceptible to fulminant meningococcal infections. …

Jan 1, 2018 · The role of properdin was confined as the only positive regulatory protein of the complement system. The function of properdin is to bind to and stabilize the nascent AP C3 …