Feb 6, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. Recognizes paired …

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Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. The …

Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau monomers …

Nov 25, 2024 · LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about the makeup of LY3954068.

Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau phosphorylated at …

Feb 1, 2023 · Secondary outcomes include brain tau deposition as per PET, the iADRS, ADASCog14, and ADCS-iADL measures of cognition and function, plus the MMSE. The trial, at 199 sites in North …

In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies specifically …

Sep 12, 2024 · A big tau variant is found in tangle-resistant brain regions such as the cerebellum. This isoform degrades quickly and resists phosphorylation and aggregation. In AD patients, big tau …

Feb 6, 2024 · The interaction of MC-1 with recombinant tau suggests that post-translational modifications are not required to generate the MC-1 epitope. However, it remains possible that post …